Photopolymers Based on Boronic Esters for the Enhanced Degradation of 3D-Printed Scaffolds

Lithography-based additive manufacturing technologies have become a valuable tool in tissue engineering for the fabrication of biocompatible and biodegradable bone regeneration scaffolds. Currently employed photopolymers based on (meth)acrylates, vinyl esters, or carbonates display undesirable properties such as irritancy cytotoxicity residual monomers, degradation via autocatalytic bulk erosion leading to implant failure, insufficient speed vivo. This work investigates monomers containing boronic ester bonds potential alternative these state-of-the-art compounds. Next facile synthesis, significantly lower was shown this generation allyl ether compared commonly utilized (meth)acrylates. Photopolymerization thiol–ene reaction showed that rigid esters led sufficient photoreactivity 3D structuring, materials with reduced shrinkage excellent mechanical can be obtained. Additionally, studies revealed accelerated desired surface under physiological acidic conditions. Ultimately, test structure out ester-based formulation successfully stereolithography-printed, showing great precursors used 3D-printed implants improved behavior without forfeiting good properties.